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Abstract
Objective Glycaemia in newborns changes significantly after birth; however, little is known about these changes. The objective was to describe continuous interstitial glucose values in term newborns who were exclusively breast fed on the first day of life.
Design We studied 159 newborns with appropriate weights for gestational age, who were exclusively breast fed on the first day of life, using a continuous glucose monitoring device that calculates interstitial glucose every 5 min. The device was removed after 24 hours, and the results were analysed using the R program, which provides the minimum, maximum, median and a standard curve with centiles.
Results At the second hour of life, the moment in which the sensor started to identify the newborn’s glycaemia, interstitial glucose levels were 2.59–4.43 mmol/L (46.7–79.9 mg/dL). The median interstitial glucose level of the newborns during the first day of life was 3.33±0.48 mmol/L (60±8.6 mg/dL). Interstitial glucose levels dropped until the sixth hour of life, reaching 2.19–3.95 mmol/L (39.5–71.1 mg/dL), and then increased again. The maximum values were found at the 20th and 21st hours of life, which were 2.81–4.64 mmol/L (50.6–83.6 mg/dL).
Conclusion The interstitial glucose during the first 24 hours of life declined until the sixth hour of life, then increased around the 20th hour and remained stable until the end of the first day of life.
- endocrinology
- neonatology
- physiology
Data availability statement
Data are available in a public, open access repository. The data supporting the findings of this study are openly available at https://doi.org/10.6084/m9.figshare.22229656.
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Data availability statement
Data are available in a public, open access repository. The data supporting the findings of this study are openly available at https://doi.org/10.6084/m9.figshare.22229656.
Footnotes
Contributors NA collected the data, performed the initial analyses and drafted and reviewed the manuscript. RDRLJ conceptualised and designed the study, acquired funding and resources, coordinated and supervised data collection and critically reviewed the manuscript for important intellectual content and are the guarantor for the study. JSC conceptualised and designed the study, assisted with the methodology and formal analysis and reviewed the manuscript. DCA assisted with the methodology, performed the formal analysis and reviewed the manuscript. CEM conceptualised and designed the study, assisted with formal analysis and reviewed the manuscript.
Funding This study was supported by FAPESP (grant number 2016/06331-7 to NA and grant number 2014/02039-4 to RLJ) and CAPES (grant number 001 to NA).
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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