Article Text

Download PDFPDF
Vertical transmission of SARS-CoV-2 – are there differences in rates of neonatal SARS-CoV-2 infection in two classification systems?
  1. Nadine Mand1,
  2. Matthias Hutten2,
  3. Rolf Felix Maier1,
  4. Lars Mense3,
  5. Ulrich Pecks4,
  6. Mario Rüdiger3
  7. on behalf of the CRONOS Network
  1. 1 Department of Pediatrics, University of Marburg, Marburg, Germany
  2. 2 Department of Pediatrics, Maastricht University, Maastricht, Netherlands
  3. 3 Department of Neonatology and Pediatric Intensive Care, Medizinische Fakultät Carl Gustav Carus, TU Dresden, Dresden, Germany
  4. 4 Department of Obstetrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
  1. Correspondence to Dr Nadine Mand, Pediatrics, University of Marburg, Marburg 35043, Germany; mandn{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Neonatal SARS-CoV-2 infection due to vertical transmission has been summarised in recent reviews.1 2 However, the comparability of the underlying case reports and case series might be limited because of the often inconsistent use of different classification systems.1

COVID-19-Related Obstetric and Neonatal Outcome Study (CRONOS) was a prospective German registry enrolling pregnant women with confirmed SARS-CoV-2 infection during their pregnancy.3 4 The registry collected data between 3 April 2020 and 10 February 2023 with 130 of 686 (18.9%) German obstetric hospitals actively participating.4 To classify the timing and the probability of mother-to-child transmission of SARS-CoV-2-positive newborns in the CRONOS cohort we used the classification systems of the Nordic Federation of Societies of Obstetrics and Gynecology (NFSOG)5 and WHO.6

Within the study period, …

View Full Text


  • Contributors NM designed and conducted the analyses reported in this study and wrote the manuscript. UP contributed significantly to the design of these analyses. MH, LM, RFM, UP and MR all contributed significantly to the final draft of this manuscript by discussing the results and their interpretations and by revising earlier drafts. UP and MR are the principal investigators of the CRONOS Network.

  • Funding The CRONOS Network received funding from CAU/UKSH, DGPM, Krumme-Stiftung Kiel and the German Society of Diabetes.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.