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Rescue high-frequency oscillatory ventilation in UK neonatal intensive care units
  1. Ourania Kaltsogianni1,
  2. Anna Howells1,
  3. Theodore Dassios1,
  4. Anne Greenough1,2
  1. 1 Department of Women and Children's Health, School of Life Sciences, Faculty of Life Science and Medicine, King's College London, London, UK
  2. 2 NIHR Biomedical Research Centre, Guy’s and St Thomas NHS Foundation Trust and King’s College London, London, UK
  1. Correspondence to Professor Anne Greenough, Department of Women and Children's Health, School of Life Sciences, Faculty of Life Science and Medicine, King's College London, London, WC2R 2LS, UK; anne.greenough{at}kcl.ac.uk

https://doi.org/10.1136/archdischild-2022-325039

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    Observational studies demonstrated improvements in gas exchange in infants who were placed on high-frequency oscillation (HFO) following failure of conventional ventilation (rescue HFO), but the few randomised controlled trials did not demonstrate important clinical benefits.1 2 Indeed, subsequent meta-analyses did not recommend routine use of rescue high-frequency oscillatory ventilation (HFOV) in infants with respiratory failure of any gestational age.3 4 Considering that data are limited, our aim was to explore use of rescue HFOV in UK neonatal units. A questionnaire was sent to all 189 UK neonatal units between May 2022 and August 2022.

    There was a 98% response rate: 57 responders from neonatal intensive care units (NICUs), 84 local neonatal units (LNUs) and 45 special care baby units …

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    Footnotes

    • Contributors AG, TD and OK designed the study and performed the data analysis. OK and AH collected the data. OK wrote the first draft. All authors were involved in the production and approval of the final draft of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests AG has held grants from various manufacturers (Abbot Laboratories and MedImmune) and ventilator manufacturers (SLE). AG received honoraria for giving lectures and advising various manufacturers (Abbot Laboratories and MedImmune) and ventilator manufacturers (SLE).

    • Provenance and peer review Not commissioned; internally peer reviewed.