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Lactate acidosis and hypoglycaemia in twin anaemia polycythemia sequence donors
  1. M.J.A. van de Sande1,
  2. E. Lopriore2,
  3. E.J.T. Verweij1,
  4. C. de Bruin3,
  5. F. Slaghekke1,
  6. L.S.A. Tollenaar1
  1. 1 Division of Fetal Medicine, Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands
  2. 2 Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
  3. 3 Division of Pediatric Endocrinology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
  1. Correspondence to M.J.A. van de Sande, Obstetrics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; m.j.a.van_de_sande{at}

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Twin anaemia polycythemia sequence (TAPS) is a monochorionic twin condition that occurs due to imbalanced chronic feto-fetal transfusion through minuscule vascular placental anastomoses, leading to anaemia in the donor twin and polycythemia in the recipient twin. Donors are significantly more at risk of developing severe long-term neurodevelopmental impairment (NDI) (18%) than recipients (3%).1 The cause for this difference in outcome is not well understood. Previous studies showed that neonatal lactate acidosis and hypoglycaemia are associated with long-term impairment.2 3 To date, the prevalence of these metabolic conditions has not been studied in TAPS. This study was set up to investigate the prevalence of lactate acidosis and hypoglycaemia in TAPS donors and recipients, to explore potential hypotheses for the difference …

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  • Contributors MJAvdS and LSAT were responsible for conceptualisation, (monitoring and interpreting) data collection, wrote the statistical analysis plan, analysed the data and drafted and revised the final paper. FS and EL were responsible for the conceptualisation, supervised in the data interpretation and reviewed and edited the final paper. CdB was responsible for monitoring and interpreting data collection and reviewed the final paper. EJTV reviewed the final paper.

  • Funding This study was funded by a research grant from the TAPS Support Foundation.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.