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We would like to thank Nobile et al for their interest in our network meta-analysis comparing the efficacy of methods for surfactant administration.1 The authors raised concerns by giving emphasis on the combination of various study designs. However, our network meta-analysis implemented a parametric design-adjusted meta-analysis in order to incorporate both randomised and non-randomised evidence in the analysis, as suggested by Efthimiou et al.2 Following this approach, various weights were placed on observational studies, enabling the …
Contributors Both authors contributed equally.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.