Responses

A randomised trial comparing weaning from CPAP alone with weaning using heated humidified high flow nasal cannula in very preterm infants: the CHiPS study
Compose Response

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests

PLEASE NOTE:

  • A rapid response is a moderated but not peer reviewed online response to a published article in a BMJ journal; it will not receive a DOI and will not be indexed unless it is also republished as a Letter, Correspondence or as other content. Find out more about rapid responses.
  • We intend to post all responses which are approved by the Editor, within 14 days (BMJ Journals) or 24 hours (The BMJ), however timeframes cannot be guaranteed. Responses must comply with our requirements and should contribute substantially to the topic, but it is at our absolute discretion whether we publish a response, and we reserve the right to edit or remove responses before and after publication and also republish some or all in other BMJ publications, including third party local editions in other countries and languages
  • Our requirements are stated in our rapid response terms and conditions and must be read. These include ensuring that: i) you do not include any illustrative content including tables and graphs, ii) you do not include any information that includes specifics about any patients,iii) you do not include any original data, unless it has already been published in a peer reviewed journal and you have included a reference, iv) your response is lawful, not defamatory, original and accurate, v) you declare any competing interests, vi) you understand that your name and other personal details set out in our rapid response terms and conditions will be published with any responses we publish and vii) you understand that once a response is published, we may continue to publish your response and/or edit or remove it in the future.
  • By submitting this rapid response you are agreeing to our terms and conditions for rapid responses and understand that your personal data will be processed in accordance with those terms and our privacy notice.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

Other responses

Jump to comment:

  • Published on:
    High CLD in nCPAP group despite high use of ANS
    • Shabih Manzar, Neonatologist Louisiana State University Health Sciences Center at Shreveport, LA, USA

    The data in the study [1] support the clinician in practicing heated humidified high-flow nasal cannula (nHF) as a viable alternative method for weaning preterm infants with a median gestational age of 28 weeks. The benefits of nHF include ease of application, earlier introductions of suck feeds, and parents’ satisfaction. While looking at the data, the nasal continuous positive airway pressure (nCPAP) group had more chronic lung disease (CLD) (OR of 0.42, favoring nHF). The question is: why nCPAP group have a significantly higher CLD despite receiving higher antenatal steroids (ANS)? The data is contradictory. ANS should be protective against the development of CLD. The nCPAP group received higher antenatal corticosteroids 48/61 (78%) compared to the nHF group 34/59 (57%). The difference in ANS use was statistically significant (as per online stats (https://www.socscistatistics.com/tests/chisquare2/default2.aspx), the chi-square statistic is 6.1481. The p-value is .013155).

    The second question is regarding the use of nHF at 8 L/min as rescue instead of bubble CPAP of 6 cm. What was the rationale?

    What is CHiPS stand for?

    Reference: 1. Clements J, Christensen PM, Meyer M. A randomised trial comparing weaning from CPAP alone with weaning using heated humidified high flow nasal cannula in very preterm infants: the CHiPS study [published online ahead of print, 2022 Jul 18]. Arc...

    Show More
    Conflict of Interest:
    None declared.