A randomised trial comparing weaning from CPAP alone with weaning using heated humidified high flow nasal cannula in very preterm infants: the CHiPS study
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  • Published on:
    High CLD in nCPAP group despite high use of ANS
    • Shabih Manzar, Neonatologist Louisiana State University Health Sciences Center at Shreveport, LA, USA

    The data in the study [1] support the clinician in practicing heated humidified high-flow nasal cannula (nHF) as a viable alternative method for weaning preterm infants with a median gestational age of 28 weeks. The benefits of nHF include ease of application, earlier introductions of suck feeds, and parents’ satisfaction. While looking at the data, the nasal continuous positive airway pressure (nCPAP) group had more chronic lung disease (CLD) (OR of 0.42, favoring nHF). The question is: why nCPAP group have a significantly higher CLD despite receiving higher antenatal steroids (ANS)? The data is contradictory. ANS should be protective against the development of CLD. The nCPAP group received higher antenatal corticosteroids 48/61 (78%) compared to the nHF group 34/59 (57%). The difference in ANS use was statistically significant (as per online stats (, the chi-square statistic is 6.1481. The p-value is .013155).

    The second question is regarding the use of nHF at 8 L/min as rescue instead of bubble CPAP of 6 cm. What was the rationale?

    What is CHiPS stand for?

    Reference: 1. Clements J, Christensen PM, Meyer M. A randomised trial comparing weaning from CPAP alone with weaning using heated humidified high flow nasal cannula in very preterm infants: the CHiPS study [published online ahead of print, 2022 Jul 18]. Arc...

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    Conflict of Interest:
    None declared.