May 2022 - Volume 107 - 3
- Safe emergency neonatal airway management: current challenges and potential approaches (21 April, 2021)
This review describes the challenges encountered with neonatal intubation, particularly in relation to training and achieving competency. It discusses strategies to optimise intubation success and examines the airway adjuncts currently available to manage the neonatal airway.
- Neuroscience meets nurture: challenges of prematurity and the critical role of family-centred and developmental care as a key part of the neuroprotection care bundle (10 May, 2021)
This review examines the developmental milestones of fetal brain and how preterm birth can disrupt this trajectory. It then outlines effective non-medical, family-centred and developmental care strategies which have the potential to improve neurodevelopmental outcomes.
- Antenatal corticosteroids and neurodevelopmental outcomes in late preterm births (29 September, 2021)
In a large population-based dataset of live births at 34-36 weeks' gestation born 2006-2011, exposure to antenatal corticosteroids earlier in gestation may be associated with an increased risk for neurodevelopmental concerns and healthcare utilization at 5-9 years.
- Temporal trends in routine predischarge pulse oximetry screening: 6 years’ experience in a UK regional neonatal unit (22 October, 2021)
This large retrospective review of over 49,000 infants examines the impact of routine pulse oximetry screening in a regional neonatal unit. Improvements in detection rates of congenital heart disease were seen, together with a reduction in the admission of healthy babies.
- Assessment of optimal chest compression depth during neonatal cardiopulmonary resuscitation: a randomised controlled animal trial (30 July, 2021)
In an asphyxiated piglet model, time to return of spontaneous circulation was similar for chest compressions 25%, 33%, and 40% anterior-posterior depth, while Increasing compression depth improved hemodynamic and respiratory parameters.
- Outcomes of very preterm infants with neonatal hyperglycaemia: a systematic review and meta-analysis (30 July, 2021)
In a systematic review and meta-analysis, hyperglycemia in very preterm infants is associated with higher odds of mortality, IVH, and ROP.
- Individualised decision making: interpretation of risk for extremely preterm infants—a survey of UK neonatal professionals (19 August, 2021)
Topical and important insight into the current state of play in the UK regarding active management at the limit of viability.
- Comparison of three intraosseous access devices for resuscitation of term neonates: a randomised simulation study (2 August, 2021)
Three different devices for intra-osseous access during were evaluated in a bone model intended to simulate insertion in term newborns. A total of 92 paediatricians were involved. Success rates were markedly different between devices.
- Monitoring of carbon dioxide in ventilated neonates: a prospective observational study (3 August, 2021)
This study comparing the precision and accuracy of end-tidal and transcutaneous pCO2 with arterial measurements found that end-tidal CO2, measured through a double-lumen ET tube in ventilated neonates, was superior to tcpCO2.
- Identification of treatment-warranted retinopathy of prematurity by neonatal nurse specialist (23 August, 2021)
This study demonstrates that screening for retinopathy of prematurity treatment can be performed by a specialist nurse practitioner obtaining and interpreting digital retinal images, with excellent agreement with treating ophthalmologists.
- Implementation of an adapted Sepsis Risk Calculator algorithm to reduce antibiotic usage in the management of early onset neonatal sepsis: a multicentre initiative in Wales, UK (22 September, 2021)
Antibiotic use in the newborn may have long lasting impact. Neonatal sepsis is relatively rare but one which causes concern, investigation and treatment. This paper describes the implementation of an sepsis risk calculator to reduce antibiotic use in a safe and sustainable way.
- Comparison of intraosseous and intravenous epinephrine administration during resuscitation of asphyxiated newborn lambs (30 August, 2021)
When intravenous access is not easily attainable, recommendations are to use intra-osseus as an alternative route for adrenaline administration in neonatal resuscitation. In an non-randomized trial in a lamb model, these two delivery routes were equivalent in terms of success in resuscitation and serum adrenaline levels.
- Mortality and significant neurosensory impairment in preterm infants: an international comparison (11 September, 2021)
The composite outcome of mortality and significant neurodisability in extremely low birth weight infants is compared across 3 different international cohorts (Canada, Australia/New Zealand, France). The composite outcome was higher in the French cohort, driven by a higher mortality.
- Neonates with mild hypoxic–ischaemic encephalopathy receiving supportive care versus therapeutic hypothermia in California (30 August, 2021)
This manuscript reports trends in the use of therapeutic hypothermia for babies with mild HIE in the NICUs in the CPQCC catchment, and assesses odds ratios for maternal and infant factors associated with the use of TH. There was an increase in the use of TH for mild HIE increased over time as a form of therapeutic creep.
- Neonatal-onset mitochondrial disease: clinical features, molecular diagnosis and prognosis (7 October, 2021)
The authors analyzed neonatal-onset mitochondrial disease in Japan via a retrospective observational study to clarify its clinical features, molecular diagnosis, and prognosis. The heterogeneous aetiology if the group is outlined.