Importance The current neonatal resuscitation guidelines recommend positive pressure ventilation via face mask or nasal prongs at birth. Using a nasal interface may have the potential to improve outcomes for newborn infants.
Objective To determine whether nasal prong/nasopharyngeal tube versus face mask during positive pressure ventilation of infants born <37 weeks’ gestation in the delivery room reduces in-hospital mortality and morbidity.
Data sources MEDLINE (through PubMed), Google Scholar and EMBASE, Clinical Trials.gov and the Cochrane Central Register of Controlled Trials through August 2019.
Study selection Randomised controlled trials comparing nasal prong/nasopharyngeal tube versus face mask during positive pressure ventilation of infants born <37 weeks’ gestation in the delivery room.
Data analysis Risk of bias was assessed using the Covidence Collaboration Tool, results were pooled into a meta-analysis using a random effects model.
Main outcome In-hospital mortality.
Results Five RCTs enrolling 873 infants were combined into a meta-analysis. There was no statistical difference in in-hospital mortality (risk ratio (RR 0.98, 95% CI 0.63 to 1.52, p=0.92, I2=11%), rate of chest compressions in the delivery room (RR 0.37, 95% CI 0.10 to 1.33, p=0.13, I2=28%), rate of intraventricular haemorrhage (RR 1.54, 95% CI 0.88 to 2.70, p=0.13, I2=0%) or delivery room intubations in infants ventilated with a nasal prong/tube (RR 0.63, 95% CI 0.39,1.02, p=0.06, I2=52%).
Conclusion In infants born <37 weeks’ gestation, in-hospital mortality and morbidity were similar following positive pressure ventilation during initial stabilisation with a nasal prong/tube or a face mask.
Data availability statement
All data relevant to the study are included in the article or uploaded as supplementary information.
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Contributors Conception: GMS, AM. Data acquisition: GMS, AM, MB. Data analysis: GMS, AM, MB. Interpreting of results: GMS, AM, MB. Drafting of the manuscript: GMS, AM, MB. Critical revision of the manuscript: GMS, AM, MB. Final approval of the manuscript: GMS, AM, MB.
Funding GMS is a recipient of the Heart and Stroke Foundation/University of Alberta Professorship of Neonatal Resuscitation, a National New Investigator of the Heart and Stroke Foundation Canada and an Alberta New Investigator of the Heart and Stroke Foundation Alberta.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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