Article Text

Download PDFPDF
Prematurity and postnatal alterations in intermittent hypoxaemia
  1. Juliann M Di Fiore1,
  2. Vidhi Shah2,
  3. Abhijit Patwardhan3,
  4. Abdus Sattar1,
  5. Shengxuan Wang1,
  6. Thomas Raffay1,
  7. Richard J Martin4,
  8. Elie G Abu Jawdeh5
  1. 1 Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
  2. 2 Division of Neonatology, Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA
  3. 3 Department of Biomedical Engineering, University of Kentucky, Lexington, Kentucky, USA
  4. 4 Department of Pediatrics, Rainbow Babies Childrens Hospital, Cleveland, Ohio, USA
  5. 5 Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA
  1. Correspondence to Dr Elie G Abu Jawdeh, Pediatrics, University of Kentucky, Lexington, KY 40506, USA; elieabujawdeh{at}gmail.com

Abstract

Intermittent hypoxaemia (IH) events are well described in extremely preterm infants, but the occurrence of IH patterns in more mature preterm infants remains unclear. The objective of this study was to characterise the effect of gestational age on early postnatal patterns of IH in extremely (<28 weeks), very (28–<32 weeks) and moderately (32–<34 weeks) preterm infants. As expected, extremely preterm infants had a significantly higher frequency of IH events of longer durations and greater time with hypoxaemia versus very and moderately preterm infants. In addition, the postnatal decrease in IH duration was comparable in the very and moderately preterm infants. This progression of IH events should assist clinicians and families in managing expectations for resolution of IH events during early postnatal life.

  • neonatology
  • health services research

Data availability statement

Data are available on reasonable request. This study contains data from two university hospital sites. This publication is a retrospective assessment of the two data sets. The data are deidentified. Reuse is not permitted without permission from the authors.

Statistics from Altmetric.com

Data availability statement

Data are available on reasonable request. This study contains data from two university hospital sites. This publication is a retrospective assessment of the two data sets. The data are deidentified. Reuse is not permitted without permission from the authors.

View Full Text

Footnotes

  • Contributors JMDF and EGAJ designed and conceptualised the study, oversaw and conducted data collection and analyses at their respective centres and wrote the initial manuscript. VS, TR and RJM designed and conceptualised the study and drafted the article. AP participated in development of the study, oversaw data collection at his centre and drafted the article. AS and SW participated in development of the study plan, performed statistical analyses and drafted the article.

  • Funding The study was funded in part by: (1) The Gerber Foundation, University of Kentucky (EGAJ, PI); (2) University of Kentucky’s National Centre for Advancing Translational Sciences, UL1RR033173; (3) TR is supported by NIH K08HL133459-03 grant; and (4) The Gerber Foundation, Case Western Reserve University (JMDF, co-investigator; Peter MacFarlane, principal investigator).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.