Background Neonatal research evaluates many different outcomes using multiple measures. This can prevent synthesis of trial results in meta-analyses, and selected outcomes may not be relevant to former patients, parents and health professionals.
Objective To define a core outcome set (COS) for research involving infants receiving neonatal care in a high-income setting.
Design Outcomes reported in neonatal trials and qualitative studies were systematically reviewed. Stakeholders were recruited for a three-round international Delphi survey. A consensus meeting was held to confirm the final COS, based on the survey results.
Participants Four hundred and fourteen former patients, parents, healthcare professionals and researchers took part in the eDelphi survey; 173 completed all three rounds. Sixteen stakeholders participated in the consensus meeting.
Results The literature reviews identified 104 outcomes; these were included in round 1. Participants proposed 10 additional outcomes; 114 outcomes were scored in rounds 2 and 3. Round 1 scores showed different stakeholder groups prioritised contrasting outcomes. Twelve outcomes were included in the final COS: survival, sepsis, necrotising enterocolitis, brain injury on imaging, general gross motor ability, general cognitive ability, quality of life, adverse events, visual impairment/blindness, hearing impairment/deafness, retinopathy of prematurity and chronic lung disease/bronchopulmonary dysplasia.
Conclusions and relevance A COS for clinical trials and other research studies involving infants receiving neonatal care in a high-income setting has been identified. This COS for neonatology will help standardise outcome selection in clinical trials and ensure these are relevant to those most affected by neonatal care.
- outcomes research
- evidence based medicine
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Contributors CG conceived of this project. JWHW, CG and JMND planned and completed the systematic review of outcomes reported in clinical trials. JWHW, CG and GB planned and completed the systematic review of outcomes identified by patients, parents and other stakeholders. The eDelphi surveys were created and run by JWHW. The results were analysed by JWHW, CG and JMND. MK chaired the consensus meeting. The first draft of the manuscript was written by JWHW; CG, JMND and NMo edited and reviewed the manuscript. It was reviewed, edited and approved by JWHW, CG, EA, IA-M, GB, AG, NJH, MK, JML, CL-D, NMa, LN, JN, AR-L, BW-E and NMo.
Funding This study was funded as part of a Medical Research Council (MRC) Clinician Scientist Fellowship awarded to CG (MR/N008405/1), salary support for JWHW from the Portland Hospital and Mason Medical Research Foundation, and unrestricted funds held by NMo. NMa receives part funding from the Department of Health’s NIHR Biomedical Research Centre’s funding scheme at UCLH/UCL. The funding bodies had no involvement in the research or this publication.
Competing interests JWHW has received support from Chiesi Pharmaceuticals to attend an educational conference and has received a research grant from Mason Medical Research Foundation. AG has held grants from various manufacturers (Abbott Laboratories, MedImmune) and ventilator manufacturers (SLE). AG has received honoraria for giving lectures and advising various manufacturers (Abbott Laboratories, MedImmune) and ventilator manufacturers (SLE). AG is currently receiving a non-conditional educational grant from SLE. NMa has received consultancy fees from Shire and Novartis and is Chair of the long-term outcomes group for the International Neonatal Consortium, Critical Path Institute. NMo is Director of the Neonatal Data Analysis Unit at Imperial College London. In the last 5 years NMo has served on the Board of Trustees of the Royal College of Paediatrics and Child Health, David Harvey Trust, Medical Women’s Federation and Medact; and is a member of the Nestle Scientific Advisory Board. NMo has received research grants from the British Heart Foundation, Medical Research Council, National Institute of Health Research, Westminster Research Fund, Collaboration for Leadership in Applied Health Research and Care Northwest London, Healthcare Quality Improvement Partnership, Bliss, Prolacta Life Sciences, Chiesi, Shire and HCA International; travel and accommodation expenses from Nutricia, Prolacta, Nestle and Chiesi; honoraria from Ferring Pharmaceuticals and Alexion Pharmaceuticals for contributions to expert advisory boards; and Chiesi for contributing to a lecture programme. CG is part of an international team developing reporting guidance (a CONSORT extension) for clinical trials using cohorts and routinely collected health data. He has received support from Chiesi Pharmaceuticals to attend an educational conference; in the past 5 years he has been investigator on received research grants from Medical Research Council, National Institute of Health Research, Canadian Institutes of Health Research, Department of Health in England, Mason Medical Research Foundation, Westminster Medical School Research Trust and Chiesi Pharmaceuticals.
Patient consent for publication Not required.
Ethics approval Research ethics approval was not required for this project. The systematic reviews undertaken did not need research ethics approval and the anonymised surveys were completed by consenting adults who opted in in response to adverts.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement Data are available upon reasonable request.
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