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We thank Pieter Degraeuwe for his letter and for highlighting the potential hidden risk of detection bias.1 Our review focused specifically upon reducing central line-associated bloostream infections (CLABSIs) and while we accept that bloodstream infection for all forms of late-onset sepsis is a useful outcome measure, its use would have complicated the interpretation of results relating to reductions in CLABSI. 2
We agree that there are multiple challenges with using CLABSI as an outcome measure, including the variety of …
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.