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Letter
Reply to: ‘Research on infection prevention bundles: hidden risk of bias?’
  1. Victoria Payne1,2,
  2. Mike Hall2,
  3. Jacqui Prieto1,2,
  4. Mark J Johnson2,3
  1. 1 School of Health Sciences, University of Southampton, Southampton, UK
  2. 2 University Hospital Southampton NHS Foundation Trust, Southampton, UK
  3. 3 NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK
  1. Correspondence to Victoria Payne, School of Health Sciences, University of Southampton, UK; vp1m14{at}soton.ac.uk

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We thank Pieter Degraeuwe for his letter and for highlighting the potential hidden risk of detection bias.1 Our review focused specifically upon reducing central line-associated bloostream infections (CLABSIs) and while we accept that bloodstream infection for all forms of late-onset sepsis is a useful outcome measure, its use would have complicated the interpretation of results relating to reductions in CLABSI. 2

We agree that there are multiple challenges with using CLABSI as an outcome measure, including the variety of …

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Footnotes

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.