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Contributors ETA, MJJ, RMB, JJA and FP conceptualised and designed the study and reviewed and revised the manuscript. AY drafted the initial manuscript and reviewed and revised the manuscript.
Funding AY, MJJ and RMB are supported by the National Institute for Health Research through the NIHR Southampton Biomedical Research Centre. JJA is funded by an Action Medical Research Training Fellowship.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.
Data sharing statement Additional unpublished data are available upon request.
Patient consent for publication Not required.