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Human milk as a protective factor for bronchopulmonary dysplasia: a systematic review and meta-analysis
  1. Jinglan Huang1,2,
  2. Li Zhang1,2,
  3. Jun Tang1,2,
  4. Jing Shi1,2,
  5. Yi Qu1,2,
  6. Tao Xiong1,2,
  7. Dezhi Mu1,2
  1. 1 Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
  2. 2 Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, Sichuan University, Chengdu, Sichuan, China
  1. Correspondence to Dr Tao Xiong, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China; tao_xiong{at}126.com

Abstract

Objective To summarise current evidence evaluating the effects of human milk on the risk of bronchopulmonary dysplasia (BPD) in preterm infants.

Design We searched for studies on human milk and BPD in English and Chinese databases on 26 July 2017. Furthermore, the references of included studies were also screened. The inclusion criteria in this meta-analysis were the following: (1) preterm infants (<37 weeks); (2) human milk; (3) comparing with formula feeding; (4) the outcome included BPD; and (5) the type of study was randomised controlled trial (RCT) or cohort study.

Result A total of 17 cohort studies and 5 RCTs involving 8661 preterm infants met our inclusion criteria. The ORs and 95% CIs of six groups were as follows: 0.78 (0.68 to 0.88) for exclusive human milk versus exclusive formula group, 0.77 (0.68 to 0.87) for exclusive human milk versus mainly formula group, 0.76 (0.68 to 0.87) for exclusive human milk versus any formula group, 0.78 (0.68 to 0.88) for mainly human milk versus exclusive formula group, 0.83 (0.69 to 0.99) for mainly human milk versus mainly formula group and 0.82 (0.73 to 0.93) for any human milk versus exclusive formula group. Notably, subgroup of RCT alone showed a trend towards protective effect of human milk on BPD but no statistical significance.

Conclusion Both exclusive human milk feeding and partial human milk feeding appear to be associated with lower risk of BPD in preterm infants. The quality of evidence is low. Therefore, more RCTs of this topic are needed.

  • human milk
  • protective factor
  • bronchopulmonary dysplasia
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Footnotes

  • JH and LZ contributed equally.

  • Contributors Conceived the review: JH, LZ and TX. Designed the review: JH, LZ and TX. Coordinated the review: all authors. Designed the search strategies: JH, LZ, YQ, TX and DM. Extracted the data: JH, LZ and TX. Wrote the review: all authors. Provided general advice on the review: TX. Secured funding for the review: TX.

  • Funding The National Science Foundation of China (No. 81330016 and 81630038 to DM, 81771634 to YQ, 81300525 to TX); the Major State Basic Research Development Program (2017YFA0104200 to DM); and Grants from Science and Technology Bureau of Sichuan Province (2016TD0002 to YQ).

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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