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In utero misoprostol exposure has been associated with Möbius sequence and terminal transverse limb defects following failed medical termination of pregnancy.1 Möbius sequence affects 1 in 50 000 live births; there is congenital facial or abducens nerve palsy and a variable association with central hypoventilation and transverse limb defects.2 3 Pathogenesis is presumed vascular disruption and hypoxic injury secondary to misoprostol-induced uterine contractions between 6 and …
Contributors FP is the author of the manuscript. JC is the supervising author. Talaat Youssef is involved in MRI analysis.
Competing interests None declared.
Patient consent Parental/guardian consent obtained.
Provenance and peer review Not commissioned; internally peer reviewed.
Collaborators Dr Talaat Youssef, Department of radiology. Dr Tommy Mousa, Department of fetal medicine. Department of medical illustration. University Hospitals of Leicester, UK.