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Images in neonatal medicine
Möbius sequence with central hypoventilation in a neonate after failed elective medical termination of pregnancy
  1. Fahim Patel,
  2. Jonathan Cusack
  1. Neonatal Unit, Leicester Royal Infirmary, Leicester, UK
  1. Correspondence to Dr Fahim Patel, Neonatal Unit, Leicester Royal Infirmary, Leicester LE1 5WW, UK; fahim.patel{at}nhs.net

https://doi.org/10.1136/archdischild-2018-315545

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    In utero misoprostol exposure has been associated with Möbius sequence and terminal transverse limb defects following failed medical termination of pregnancy.1 Möbius sequence affects 1 in 50 000 live births; there is congenital facial or abducens nerve palsy and a variable association with central hypoventilation and transverse limb defects.2 3 Pathogenesis is presumed vascular disruption and hypoxic injury secondary to misoprostol-induced uterine contractions between 6 and …

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    Footnotes

    • Contributors FP is the author of the manuscript. JC is the supervising author. Talaat Youssef is involved in MRI analysis.

    • Competing interests None declared.

    • Patient consent Parental/guardian consent obtained.

    • Provenance and peer review Not commissioned; internally peer reviewed.

    • Collaborators Dr Talaat Youssef, Department of radiology. Dr Tommy Mousa, Department of fetal medicine. Department of medical illustration. University Hospitals of Leicester, UK.