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Severe retinopathy of prematurity predicts delayed white matter maturation and poorer neurodevelopment
  1. Torin J A Glass1,2,
  2. Vann Chau1,2,3,
  3. Jane Gardiner3,4,
  4. Justin Foong2,
  5. Jillian Vinall5,
  6. Jill G Zwicker3,6,7,8,
  7. Ruth E Grunau3,9,
  8. Anne Synnes3,9,
  9. Kenneth J Poskitt3,10,
  10. Steven P Miller1,2,3
  1. 1Department of Pediatrics (Neurology), University of Toronto and the Hospital for Sick Children, Toronto, Canada
  2. 2Neurosciences & Mental Health, SickKids Research Institute, Toronto, Canada
  3. 3BC Children’s Hospital Research Institute, Vancouver, Canada
  4. 4Department of Ophthalmology and Vision Science, University of British Columbia and BC Children’s Hospital, Vancouver, Canada
  5. 5Department of Anesthesiology, University of Calgary, Calgary, Canada
  6. 6Department of Pediatrics (Developmental Pediatrics), University of British Columbia and BC Children’s and Women’s Hospitals, Vancouver, Canada
  7. 7Department of Occupational Science and Occupational Therapy, Vancouver, Canada
  8. 8Sunny Hill Health Centre for Children, Vancouver, Canada
  9. 9Department of Pediatrics (Neonatology), University of British Columbia and BC Children’s and Women’s Hospitals, Vancouver, Canada
  10. 10Department of Radiology, University of British Columbia and BC Children’s Hospital, Vancouver, Canada
  1. Correspondence to Steven P Miller, Department of Pediatrics (Neurology), University of Toronto and the Hospital for Sick Children, Toronto (Ontario) M5G 1X8, Canada; steven.miller{at}sickkids.ca

Footnotes

  • Contributors TJAG and VC had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study design and conduct of the study: TJAG, VC, JG, SPM. Collection, management, analysis and interpretation of the data: TJAG, VC, JG, AS, JGZ, JV, REG, JF, KJP, SPM. Drafting of the manuscript: TJAG. Critical revision of the manuscript for important intellectual content: VC, JG, AS, JGZ, JV, REG, SPM. Statistical analysis: TJAG, VC, SPM. Administrative, technical or material support: TJAG, VC, JG, AS, JGZ, REG, SPM.

  • Funding Canadian Institutes for Health Research (CIHR) operating grant MOP-79262 (SPM) and MOP-86489 (REG). SPM is supported by the Bloorview Children’s Hospital Chair in Pediatric Neuroscience. REG holds a Senior Scientist Salary Award from the BC Children’s Hospital Research Institute. JGZ is funded by the Michael Smith Foundation, Canadian Child Health Clinician Scientist Program and CIHR. JV is supported by the Louise and Allan Edward Foundation. TJAG’s research funding is provided by the UBC Clinician Investigator Program and is currently an MSc student of the University of Toronto.

  • Competing interests None declared.

  • Patient consent Consent obtained from guardian.

  • Ethics approval University of British Columbia/ Women’s and Children’s Research Ethics Board.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Unpublished data from this study are not currently available to researchers outside of the study team approved by our research ethics committees.

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Footnotes

  • Contributors TJAG and VC had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study design and conduct of the study: TJAG, VC, JG, SPM. Collection, management, analysis and interpretation of the data: TJAG, VC, JG, AS, JGZ, JV, REG, JF, KJP, SPM. Drafting of the manuscript: TJAG. Critical revision of the manuscript for important intellectual content: VC, JG, AS, JGZ, JV, REG, SPM. Statistical analysis: TJAG, VC, SPM. Administrative, technical or material support: TJAG, VC, JG, AS, JGZ, REG, SPM.

  • Funding Canadian Institutes for Health Research (CIHR) operating grant MOP-79262 (SPM) and MOP-86489 (REG). SPM is supported by the Bloorview Children’s Hospital Chair in Pediatric Neuroscience. REG holds a Senior Scientist Salary Award from the BC Children’s Hospital Research Institute. JGZ is funded by the Michael Smith Foundation, Canadian Child Health Clinician Scientist Program and CIHR. JV is supported by the Louise and Allan Edward Foundation. TJAG’s research funding is provided by the UBC Clinician Investigator Program and is currently an MSc student of the University of Toronto.

  • Competing interests None declared.

  • Patient consent Consent obtained from guardian.

  • Ethics approval University of British Columbia/ Women’s and Children’s Research Ethics Board.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Unpublished data from this study are not currently available to researchers outside of the study team approved by our research ethics committees.

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