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Propofol for sedation during less invasive surfactant administration in preterm infants
  1. Claire Sophie Descamps1,
  2. Marie Chevallier1,2,
  3. Anne Ego2,
  4. Isabelle Pin3,
  5. Chloé Epiard1,
  6. Thierry Debillon1,2,4
  1. 1 Neonatal Intensive Care Unit, CHU de Grenoble, Grenoble, 38 043 Grenoble Cedex 9, France
  2. 2 Grenoble Alps University, CNRS, TIMC-IMAG, UMR 5525 ThEMAS, Grenoble, France
  3. 3 Département de pédiatrie - Centre mucoviscidose, CHU de Grenoble, Hôpital Albert Michallon, Grenoble, France
  4. 4 Univ Grenoble Alpes, Grenoble, France
  1. Correspondence to Professor Thierry Debillon, Grenoble Alps University, CNRS, TIMC-IMAG, UMR 5525 ThEMAS, Grenoble, France; tdebillon{at}

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Less invasive surfactant administration (LISA) in preterm infants with respiratory distress syndrome avoids mechanical ventilation and may further reduce the risk of death or bronchopulmonary dysplasia.1 A recent European survey indicates that the percentage of centres using LISA increased, but with wide variation in procedure. In particular, there is no consensus about whether sedation should be used.2 International guidelines recommend sedation for intubation but it can hamper spontaneous breathing, which is necessary for LISA. Recently, a study compared two groups …

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  • Contributors All the authors contributed to the study.

    CSD and MC collected the data and wrote the manuscript.

    AE and IP participated in reviewing the manuscript.

    CE contributed to the data collection.

    TD designed the study and contributed to reviewing the manuscript.

  • Competing interests None declared.

  • Ethics approval French Committee of Evaluation for Protocol Research Observational (authorization no 2016-041).

  • Provenance and peer review Not commissioned; internally peer reviewed.