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Implementation of the NICE prevention and treatment of early onset neonatal infection guideline: the Glasgow experience
  1. Jennifer Mitchell1,
  2. Sandy Kirolos2,
  3. Lesley Jackson2,
  4. Andrew Powls3
  1. 1 Neonatal Unit, Royal Hospital for Children, Glasgow, UK
  2. 2 Neonatal Department, Queen Elizabeth University Hospital, Glasgow, UK
  3. 3 Neonatal Department, Princess Royal Maternity Hospital, Glasgow, UK
  1. Correspondence to Dr Jennifer Mitchell, Neonatal Unit, Royal Hospital for Children, 1345 Govan Road, Glasgow G51 4TF, UK; Jennifermitchell4{at}

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The 2012 National Institute for Health and Care Excellence (NICE) guideline for prevention and treatment of neonatal early onset sepsis (EOS)1 has been subject to much debate since its publication. We have read with interest the experiences from other maternity units2–5 that have adopted this guideline. In contrast to these negative experiences, in Glasgow we have observed a positive impact following implementation in two large perinatal centres.

The recommended changes aim to prioritise antibiotic treatment for infants most likely to develop EOS, while minimising antibiotic exposure and reducing hospital stay for those at less risk. NICE …

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  • Collaborators Jessica Burgess-Shannon, Natalie Smee, Kirsty McManus, Claire Cockburn and Carolyn Abernethy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • Data sharing statement The authors would be happy to share data, securely, with interested parties.