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Effect of surgical ligation of the patent ductus arteriosus on cerebral perfusion of premature infants in the postoperative period
  1. A T MacLaren,
  2. A M Heuchan
  1. Neonatal Unit, Royal Hospital for Children, Glasgow, Scotland, UK
  1. Correspondence to Dr A T MacLaren, Neonatal Unit, Royal Hospital for Children, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK; andrew.maclaren{at}

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Research into the effects of surgical ligation of the ductus arteriosus (DA) on regional tissue perfusion is limited. Near-infrared spectroscopy (NIRS) is a non-invasive technique for monitoring regional mixed arteriovenous saturations in capillary beds. Previous data suggest that DA closure may result in impaired cerebral perfusion1 because of alterations in pulmonary mechanics or cardiac function.2 These changes have been implicated in the aetiology of adverse neurodevelopmental outcome in neonates after DA ligation.3 In our neonatal unit, around 20 DA ligations are performed per year. Cerebral NIRS is routinely applied perioperatively using a non-adhesive positioning technique. …

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  • Contributors The data extraction and writing of the body of the manuscript was carried out by ATM. AMH defined the clinical question, supervised the data extraction and edited the manuscript.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.