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Early onset neonatal sepsis: diagnostic dilemmas and practical management
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  • Published on:
    In response to: Early onset neonatal sepsis: diagnostic dilemmas and practical management.
    • Job LB Gieling, Pediatric resident
    • Other Contributors:
      • C Kramers, HWHA Fleuren, GPJM Gerrits, and BA Semmekrot

    We read with interest the review by AR Bedford Russell and F Kumar[1] about challenges in diagnosing EONS. The authors state to await a 100% sensitive and 100% specific test. In theory, this gold standard is obtained by observing infants while withholding antibiotics, which obviously is unacceptable. Instead combinations of laboratory and clinical signs are used to exclude EONS. Understandably, these tests must have hi...

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    Conflict of Interest:
    None declared.
  • Published on:
    Re: I know you don't like our American brand of English, but......

    We thank Dr Perlin for his response which specifically refers to the prevention of early onset Group B streptococcus (GBS) infection.

    Similar declines in GBS EONS have been seen in many other countries that have introduced screening for GBS and IAP. In contrast, in the UK the RCOG recommendation for a risk based approach has not been associated with a fall in the incidence of GBS EONS. If the incidence fell by 75%,...

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    Conflict of Interest:
    None declared.
  • Published on:
    I know you don't like our American brand of English, but......

    Dear Sir:

    I have read the most excellent review of early onset neonatal sepsis (EONS) published recently in these Archives by Dr's Bedford Russell and Kumar. We, in America, have witnessed the gradual evolution from a risk factor approach initially advocated by the American College of Obstetricians and Gynecologists, (as opposed to universal screening during gestation, as recommended by the American Academy of P...

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    Conflict of Interest:
    None declared.