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Early onset neonatal sepsis: diagnostic dilemmas and practical management


Early onset neonatal sepsis is persistently associated with poor outcomes, and incites clinical practice based on the fear of missing a treatable infection in a timely fashion. Unnecessary exposure to antibiotics is also hazardous. Diagnostic dilemmas are discussed in this review, and suggestions offered for practical management while awaiting a more rapidly available ‘gold standard’ test; in an ideal world, this test would be 100% sensitive and 100% specific for the presence of organisms.

  • Neonatology
  • Evidence Based Medicine
  • Infectious Diseases
  • Immunology
  • Microbiology

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