Objective To determine whether re-feeding of gastric residual volumes reduces the time needed to achieve full enteral feeding in preterm infants.
Design Parallel-group randomised controlled trial with a 1:1 allocation ratio.
Setting Regional referral neonatal intensive care unit.
Patients 72 infants of gestational age 230/7 to 286/7 weeks receiving minimal enteral nutrition (<24 mL/kg/day) during the first week after birth.
Interventions Infants were randomised to either be re-fed with gastric residual volumes (Re-feeding group) or receive fresh formula/human milk (Fresh-feeding group) whenever large gastric residual volumes were noted.
Main outcome measure The primary efficacy end point was time to achieve full enteral feeding (≥120 mL/kg/day) after randomisation.
Results The mean time to full enteral feeding was 10.0 days in the Re-feeding group and 11.3 days in the Fresh-feeding group (mean difference favouring re-feeding: −1.3 days; 95% CI −2.9 to 0.3; p=0.11). The composite safety end point of spontaneous intestinal perforation, surgical necrotising enterocolitis, or death occurred in 6 of 36 infants (17%) in the Re-feeding group versus 10 of 36 infants (28%) in the Fresh-feeding group (p=0.26).
Conclusions Re-feeding gastric residual volumes in extremely preterm infants does not reduce time to achieve full enteral feeding. This trial suggests that re-feeding might be as safe as fresh feeding, but further research is needed, due to lack of sufficient statistical power in this study for safety analysis.
Trial registration number NCT01420263NCT01420263.
- Infant Feeding
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