Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial

Joepe J Kaandorp; Manon J N L Benders; Ewoud Schuit; Carin M A Rademaker; Martijn A Oudijk; Martina M Porath; Sidarto Bambang Oetomo; Maurice G A J Wouters; Ruurd M van Elburg; Maureen T M Franssen; Arie F Bos; Timo R de Haan; Janine Boon; Inge P de Boer; Robbert J P Rijnders; Corrie J W F M Jacobs; Liesbeth H C J Scheepers; Danilo A W Gavilanes; Kitty W M Bloemenkamp; Monique Rijken; Claudia A van Meir; Jeannette S von Lindern; Anjoke J M Huisjes; Saskia C M J E R Bakker; Ben W J Mol; Gerard H A Visser; Frank Van Bel; Jan B Derks

doi:10.1136/archdischild-2014-306769

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Original article

Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial

Authors

Joepe J Kaandorp Department of Perinatology, University Medical Center, Utrecht, The Netherlands PubMed articles Google scholar articles
Manon J N L Benders Department of Perinatology, University Medical Center, Utrecht, The Netherlands PubMed articles Google scholar articles
Ewoud Schuit Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands PubMed articles Google scholar articles
Carin M A Rademaker Department of Clinical Pharmacy, University Medical Center, Utrecht, The Netherlands PubMed articles Google scholar articles
Martijn A Oudijk Department of Perinatology, University Medical Center, Utrecht, The Netherlands PubMed articles Google scholar articles
Martina M Porath Department of Perinatology, Maxima Medical Center, Veldhoven, The Netherlands PubMed articles Google scholar articles
Sidarto Bambang Oetomo Department of Perinatology, Maxima Medical Center, Veldhoven, The Netherlands PubMed articles Google scholar articles
Maurice G A J Wouters Department of Perinatology, VU Medical Center, Amsterdam, The Netherlands PubMed articles Google scholar articles
Ruurd M van Elburg Department of Perinatology, VU Medical Center, Amsterdam, The Netherlands Danone Research, Wageningen, The Netherlands PubMed articles Google scholar articles
Maureen T M Franssen Department of Perinatology, University Medical Center, Groningen, The Netherlands PubMed articles Google scholar articles
Arie F Bos Department of Perinatology, University Medical Center, Groningen, The Netherlands PubMed articles Google scholar articles
Timo R de Haan Department of Perinatology, Academic Medical Center, Amsterdam, The Netherlands PubMed articles Google scholar articles
Janine Boon Department of Perinatology, Diakonessenhuis, Utrecht, The Netherlands PubMed articles Google scholar articles
Inge P de Boer Department of Perinatology, Diakonessenhuis, Utrecht, The Netherlands PubMed articles Google scholar articles
Robbert J P Rijnders Department of Perinatology, Jeroen Bosch Medical Center, Den Bosch, The Netherlands PubMed articles Google scholar articles
Corrie J W F M Jacobs Department of Perinatology, Jeroen Bosch Medical Center, Den Bosch, The Netherlands PubMed articles Google scholar articles
Liesbeth H C J Scheepers Department of Perinatology, Maastricht University Medical Center, Maastricht, The Netherlands PubMed articles Google scholar articles
Danilo A W Gavilanes Department of Perinatology, Maastricht University Medical Center, Maastricht, The Netherlands PubMed articles Google scholar articles
Kitty W M Bloemenkamp Department of Perinatology, Leids University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles
Monique Rijken Department of Perinatology, Leids University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles
Claudia A van Meir Department of Perinatology, Groene Hart Hospital, Gouda, The Netherlands PubMed articles Google scholar articles
Jeannette S von Lindern Department of Perinatology, Groene Hart Hospital, Gouda, The Netherlands PubMed articles Google scholar articles
Anjoke J M Huisjes Department of Perinatology, Gelre Hospitals, Apeldoorn, The Netherlands PubMed articles Google scholar articles
Saskia C M J E R Bakker Department of Perinatology, Gelre Hospitals, Apeldoorn, The Netherlands PubMed articles Google scholar articles
Ben W J Mol Department of Perinatology, University Medical Center, Groningen, The Netherlands PubMed articles Google scholar articles
Gerard H A Visser Department of Perinatology, University Medical Center, Utrecht, The Netherlands PubMed articles Google scholar articles
Frank Van Bel Department of Perinatology, University Medical Center, Utrecht, The Netherlands PubMed articles Google scholar articles
Jan B Derks Department of Perinatology, University Medical Center, Utrecht, The Netherlands PubMed articles Google scholar articles

Correspondence to Dr Joepe J Kaandorp, University Medical Center Utrecht, Room 04.123.1, PO Box 85090, Utrecht 3508 AB, The Netherlands; j.j.kaandorp{at}umcutrecht.com, j.j.kaandorp{at}gmail.com

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Citation

Kaandorp JJ, Benders MJNL, Schuit E, et al

Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial

Archives of Disease in Childhood - Fetal and Neonatal Edition 2015;100:F216-F223.

Publication history

Received May 12, 2014
Revised November 10, 2014
Accepted November 17, 2014
First published December 15, 2014.

Online issue publication

October 26, 2017

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