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Management of neonatal early onset sepsis (CG149): compliance of neonatal units in the UK with NICE recommendations
  1. Arindam Mukherjee1,
  2. Babu Ramalingaiah1,
  3. Nigel Kennea2,
  4. Donovan Alistair Duffy2
  1. 1Department of Neonatology, St Mary's Hospital, Manchester, UK
  2. 2Department of Neonatology, St George's University Hospital, London, UK
  1. Correspondence to Dr Arindam Mukherjee, Department of Neonatology, St Mary's Hospital, Oxford Road, Manchester M13 9WL, UK; arindam.mukherjee{at}

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In August 2012, new national guidance (National Institute of Clinical Excellence) for management of Early Onset Sepsis (EOS) was introduced in the UK. The guidance outlined a strategy for new-born septic screens based on risk factors, and uses biochemical (eg, C-reactive protein, CRP) and clinical parameters to guide management. In particular, it advises a second CRP 18–24 h into treatment to help determine length of antibiotic course, and whether to perform lumbar puncture (LP). A short research report based on local experience at St George’s University Hospital, London, demonstrated that repeat CRPs led to further investigations, increased LPs, duration of treatment and stay. This impacted on workload, costs and may have an influence on general parental experience of birth in the first …

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  • Contributors Project conceived by AM. Data collected by AM, AB and BR. Data analysed by AM, NK and DAD.

  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.