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In August 2012, new national guidance (National Institute of Clinical Excellence) for management of Early Onset Sepsis (EOS) was introduced in the UK. The guidance outlined a strategy for new-born septic screens based on risk factors, and uses biochemical (eg, C-reactive protein, CRP) and clinical parameters to guide management. In particular, it advises a second CRP 18–24 h into treatment to help determine length of antibiotic course, and whether to perform lumbar puncture (LP). A short research report based on local experience at St George’s University Hospital, London, demonstrated that repeat CRPs led to further investigations, increased LPs, duration of treatment and stay. This impacted on workload, costs and may have an influence on general parental experience of birth in the first …
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