Caregiving and the stress process: An overview of concepts and their measures
LI Pearlin, JT Mullan, SJ Semple, MM Skaff - The gerontologist, 1990 - academic.oup.com
This paper views caregiver stress as a consequence of a process comprising a number of
interrelated conditions, including the socioeconomic characteristics and resources of …
interrelated conditions, including the socioeconomic characteristics and resources of …
Respiratory risks from household air pollution in low and middle income countries
A third of the world's population uses solid fuel derived from plant material (biomass) or coal
for cooking, heating, or lighting. These fuels are smoky, often used in an open fire or simple …
for cooking, heating, or lighting. These fuels are smoky, often used in an open fire or simple …
COPD and chronic bronchitis risk of indoor air pollution from solid fuel: a systematic review and meta-analysis
Background Over half the world is exposed daily to the smoke from combustion of solid
fuels. Chronic obstructive pulmonary disease (COPD) is one of the main contributors to the …
fuels. Chronic obstructive pulmonary disease (COPD) is one of the main contributors to the …
Rational design of cationic lipids for siRNA delivery
SC Semple, A Akinc, J Chen, AP Sandhu, BL Mui… - Nature …, 2010 - nature.com
We adopted a rational approach to design cationic lipids for use in formulations to deliver
small interfering RNA (siRNA). Starting with the ionizable cationic lipid 1, 2-dilinoleyloxy-3 …
small interfering RNA (siRNA). Starting with the ionizable cationic lipid 1, 2-dilinoleyloxy-3 …
The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
A Akinc, MA Maier, M Manoharan, K Fitzgerald… - Nature …, 2019 - nature.com
The regulatory approval of Onpattro, a lipid nanoparticle-based short interfering RNA drug
for the treatment of polyneuropathies induced by hereditary transthyretin amyloidosis, paves …
for the treatment of polyneuropathies induced by hereditary transthyretin amyloidosis, paves …
[HTML][HTML] In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels
T Rothgangl, MK Dennis, PJC Lin, R Oka… - Nature …, 2021 - nature.com
Most known pathogenic point mutations in humans are C• G to T• A substitutions, which can
be directly repaired by adenine base editors (ABEs). In this study, we investigated the …
be directly repaired by adenine base editors (ABEs). In this study, we investigated the …
[HTML][HTML] Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures
SC Semple, SK Klimuk, TO Harasym… - … et Biophysica Acta (BBA …, 2001 - Elsevier
Typical methods used for encapsulating antisense oligodeoxynucleotides (ODN) and
plasmid DNA in lipid vesicles result in very low encapsulation efficiencies or employ cationic …
plasmid DNA in lipid vesicles result in very low encapsulation efficiencies or employ cationic …
[HTML][HTML] Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes.
A Chonn, SC Semple, PR Cullis - Journal of Biological Chemistry, 1992 - Elsevier
The proteins associated with liposomes in the circulation of mice were analyzed in order to
determine whether bound proteins significantly influence the fate of liposomes in vivo …
determine whether bound proteins significantly influence the fate of liposomes in vivo …
Environmental risk factors for Parkinson's disease and parkinsonism: the Geoparkinson study
Objective: To investigate the associations between Parkinson's disease and other
degenerative parkinsonian syndromes and environmental factors in five European …
degenerative parkinsonian syndromes and environmental factors in five European …
Antibacterial activity of traditional Australian medicinal plants
EA Palombo, SJ Semple - Journal of ethnopharmacology, 2001 - Elsevier
Fifty-six ethanolic extracts of various parts of 39 plants used in traditional Australian
Aboriginal medicine were investigated for their antibacterial activities against four Gram …
Aboriginal medicine were investigated for their antibacterial activities against four Gram …