Cell based therapies are being assessed for their therapeutic potential across a variety of
diseases. Gestational tissues are attractive sources for cell therapy. The large number of …

Objective Umbilical cord milking (UCM) at birth may benefit preterm infants, but the
physiological effects of UCM are unknown. We compared the physiological effects of two …

Therapeutic benefits of mesenchymal stem cells (MSCs) are now widely believed to come
from their paracrine signalling, ie secreted factors such as cytokines, chemokines, and …

Objective—The objective of this study was to investigate the effect of intravenous maternal
sildenafil citrate (SC) administration on vascular function in growth-restricted fetal sheep …

Key points Fetal growth restriction induces a haemodynamic response that aims to maintain
blood flow to vital organs such as the brain, in the face of chronic hypoxaemia Maternal …

Introduction Fetal growth restriction (FGR) is a common pregnancy complication, caused by
placental insufficiency, with serious adverse consequences for development in utero and …

Erythropoietin (EPO) is being trialled in preterm infants to reduce brain injury, but high doses
increase lung injury in ventilated preterm lambs. We aimed to determine whether early …

Background Neurovascular coupling leads to an increase in local cerebral blood flow and
oxygenation in response to increased neural activity. Reduced cerebral functional …

Mechanical ventilation of preterm neonates causes lung inflammation and injury, with
potential life-long consequences. Inert 50-nm polystyrene nanoparticles (PS50G) reduce …

Background In the adult brain, increases in neural activity lead to increases in local blood
flow. However, in the preterm neonate, studies of cerebral functional haemodynamics have …