Elimination half-life of vitamin K1 in neonates is longer than is generally assumed: implications for the prophylaxis of haemorrhaghic disease of the newborn

Eur J Clin Pharmacol. 1996;49(5):421-3. doi: 10.1007/BF00203790.
No abstract available

Publication types

  • Letter

MeSH terms

  • Biomarkers*
  • Dose-Response Relationship, Drug
  • Half-Life
  • Hemostatics / administration & dosage
  • Hemostatics / blood*
  • Hemostatics / therapeutic use
  • Humans
  • Infant, Newborn
  • Protein Precursors / analysis
  • Protein Precursors / metabolism*
  • Prothrombin / analysis
  • Prothrombin / metabolism*
  • Regression Analysis
  • Vitamin K 1 / administration & dosage
  • Vitamin K 1 / pharmacokinetics*
  • Vitamin K 1 / therapeutic use
  • Vitamin K Deficiency Bleeding / prevention & control*

Substances

  • Biomarkers
  • Hemostatics
  • Protein Precursors
  • acarboxyprothrombin
  • Vitamin K 1
  • Prothrombin