We report a case of unexpected sudden cardiac arrest in an extremely low birth weight infant on the eighth day after a percutaneous silicone rubber central venous catheter was inserted for parenteral nutrition. The unique pathologic condition of infiltration of the myocardium with probably intralipid and degeneration of myocardial fibers over the right atrium and part of the right ventricle has not been reported in the past. There was no pericardial effusion. A brief review of the complications of central venous catheters is given.