Bacterial-induced activation of erythrocyte T-antigen complicating necrotising enterocolitis: a case report

R H Mupanemunda; C F Kenyon; M J Inwood; K Leigh

doi:10.1007/BF01956745

Bacterial-induced activation of erythrocyte T-antigen complicating necrotising enterocolitis: a case report

Eur J Pediatr. 1993 Apr;152(4):325-6. doi: 10.1007/BF01956745.

Authors

R H Mupanemunda¹, C F Kenyon, M J Inwood, K Leigh

Affiliation

¹ Department of Paediatrics, University of Western Ontario, London, Canada.

PMID: 8482283
DOI: 10.1007/BF01956745

Abstract

Erythrocyte Thomsen-Friedenreich crypt antigen (T-antigen) activation is not an uncommon event in infants with severe necrotising enterocolitis (NEC). Transfusion of these infants with blood products containing plasma carries the risk of causing intravascular haemolysis. T-antigen activation is easily detected using a rapid simple lectin agglutination test. Early recognition of T-antigen activation ensures the correct choice of plasma free transfusion therapy. We describe an infant with severe NEC complicated by T-antigen activation and haemolysis.

Publication types

Case Reports

MeSH terms

Antigens, Tumor-Associated, Carbohydrate / immunology*
Clostridium perfringens*
Enterocolitis, Pseudomembranous / immunology*
Hemolysis
Humans
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / immunology*
Lymphocyte Activation*
Male

Substances

Antigens, Tumor-Associated, Carbohydrate
Thomsen-Friedenreich antigen