Abstract
Liver disease in the fetus and neonate may be associated with maternal Sjögren's syndrome (neonatal lupus erythematosus). The infant of a mother with Sjögren's syndrome and high anti-Ro/SS-A and anti-La/SS-B antibody titers presented at 2 1/2 weeks of age with overwhelming hepatic insufficiency and died at 6 weeks of age. Autopsy confirmed the antemortem diagnosis of neonatal hemochromatosis. We discuss the possibility of a relationship between these two conditions.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antibodies, Antinuclear / blood*
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Autoantigens / immunology
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Fatal Outcome
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Female
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Hemochromatosis / immunology*
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Hemochromatosis / pathology
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Humans
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Infant, Newborn
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Pregnancy
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Pregnancy Complications / immunology*
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RNA, Small Cytoplasmic*
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Ribonucleoproteins / immunology
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SS-B Antigen
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Sjogren's Syndrome / immunology*
Substances
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Antibodies, Antinuclear
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Autoantigens
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RNA, Small Cytoplasmic
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RO60 protein, human
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Ribonucleoproteins
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SS-A antigen