Abstract
This article presents a comprehensive review of the patent ductus arteriosus which so often affects the premature neonate. Included are a discussion of the unique anatomy and physiology of the ductus, a review of the mechanisms involved in normal closure, and factors leading to persistent patency. Various therapeutic options also are discussed, including some new and innovative approaches.
MeSH terms
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Ductus Arteriosus / anatomy & histology
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Ductus Arteriosus / drug effects
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Ductus Arteriosus / physiology
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Ductus Arteriosus, Patent / drug therapy*
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Ductus Arteriosus, Patent / pathology
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Ductus Arteriosus, Patent / physiopathology*
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Female
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Humans
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Indomethacin / administration & dosage
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Indomethacin / pharmacology
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Indomethacin / therapeutic use*
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Infant, Newborn
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Infant, Premature*
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Infant, Premature, Diseases / drug therapy*
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Infant, Premature, Diseases / physiopathology*
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Oxygen / blood
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Pregnancy
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Prostaglandins / physiology*
Substances
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Prostaglandins
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Oxygen
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Indomethacin