Abstract
A thyrotoxic infant was delivered to a woman with a long-standing history of Hashimoto's thyroiditis, but with no evidence of Graves' disease. Long-acting thyroid stimulator (LATS) and LATS protector were absent, but thyroid-stimulating antibody was transiently present in the infant and markedly and persistently elevated in the mother. It is concluded that the maternal level of thyroid-stimulating immunoglobulins determines the presence and duration of transient neonatal thyrotoxicosis, and that thyroid-stimulating antibody is distinct from LATS and LATS protector.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antibodies / immunology*
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Female
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Humans
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Hyperthyroidism / congenital*
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Hyperthyroidism / immunology
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Immunoglobulin G / blood
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Immunoglobulins, Thyroid-Stimulating
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Infant
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Long-Acting Thyroid Stimulator / blood
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Male
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Pregnancy
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Pregnancy Complications / immunology*
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Thyroid Gland / immunology
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Thyroiditis, Autoimmune / complications*
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Thyroiditis, Autoimmune / immunology
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Time Factors
Substances
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Antibodies
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Immunoglobulin G
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Immunoglobulins, Thyroid-Stimulating
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Long-Acting Thyroid Stimulator