Abstract
Changes in mean arterial blood-pressure produced in five sick newborn infants by transfusion or exchange of blood products were accompanied by striking increases in cerebral blood-flow. These increases imply a failure of autoregulation. Four of the infants had a fatal intraventricular haemorrhage within 12 h of the observed change in flow. This suggests that the increase in flow precipitated the haemorrhage.
MeSH terms
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Blood Pressure
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Brain / blood supply*
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Cerebral Hemorrhage / etiology*
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Cerebrovascular Circulation*
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Exchange Transfusion, Whole Blood / adverse effects
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Homeostasis*
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Humans
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Hypotension / physiopathology
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Hypotension / therapy
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Infant, Newborn
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Infant, Premature, Diseases / etiology*
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Infant, Premature, Diseases / physiopathology
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Infant, Premature, Diseases / therapy
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Jaundice, Neonatal / physiopathology
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Jaundice, Neonatal / therapy
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Plasma
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Regional Blood Flow
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Serum Albumin / administration & dosage
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Transfusion Reaction*