Abstract
Twenty-one women were studied who had received propylthiouracil or methimazole during 26 pregnancies. Four of the infants had a goiter at birth, and 3 of these had neonatal thyrotoxicosis. In 2 children neonatal thyrotoxicosis was not evident at birth because of maternal antithyroid therapy. Five children had congenital defects. Two mothers were responsible for 4 of the children with abnormalities, and both mothers had been treated with thiourea drugs for long periods, ranging from 7 to 11 years. The majority of children who are exposed to these drugs in utero appear to have no subsequent ill effects. However, prolonged therapy with these agents may be undesirable.
MeSH terms
-
Abnormalities, Drug-Induced / etiology*
-
Abortion, Spontaneous
-
Adult
-
Female
-
Fetal Blood / analysis
-
Fetal Death / chemically induced
-
Goiter / chemically induced
-
Humans
-
Hyperthyroidism / chemically induced
-
Hyperthyroidism / drug therapy*
-
Infant
-
Infant, Newborn
-
Infant, Newborn, Diseases / chemically induced*
-
Long-Acting Thyroid Stimulator / analysis
-
Male
-
Methimazole / adverse effects*
-
Methimazole / therapeutic use
-
Pregnancy
-
Pregnancy Complications / drug therapy*
-
Propylthiouracil / adverse effects*
-
Propylthiouracil / therapeutic use
-
Scalp / abnormalities
-
Thyroid Function Tests
-
Thyroxine / blood
Substances
-
Methimazole
-
Propylthiouracil
-
Long-Acting Thyroid Stimulator
-
Thyroxine