Abstract
The immunogenecity of a recombinant yeast-derived hepatitis B vaccine in 25 premature infants who were born to HBsAg negative mothers was studied. The gestational ages were 28-37 weeks and birth weights were 1300-2000 grams. Seroconversion occurred in 22 infants, the anti HBs titers varied between 50 and 13,470 IU/L (Geometric mean titer = 542 IU/L). Seroconversion rate = 88%. The response did not vary with gestational age, birth weight or illness status.
MeSH terms
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Hepatitis B Antibodies / biosynthesis*
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Hepatitis B Surface Antigens / immunology*
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Hepatitis B Vaccines
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Humans
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Infant, Newborn
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Infant, Premature / immunology*
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Vaccines, Synthetic / administration & dosage
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Vaccines, Synthetic / immunology*
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Viral Hepatitis Vaccines / administration & dosage
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Viral Hepatitis Vaccines / immunology*
Substances
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Hepatitis B Antibodies
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Hepatitis B Surface Antigens
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Hepatitis B Vaccines
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Vaccines, Synthetic
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Viral Hepatitis Vaccines