Bleomycin-detectable iron in the plasma of premature and full-term neonates

P J Evans; R Evans; I Z Kovar; A F Holton; B Halliwell

doi:10.1016/0014-5793(92)80521-h

Bleomycin-detectable iron in the plasma of premature and full-term neonates

FEBS Lett. 1992 Jun 1;303(2-3):210-2. doi: 10.1016/0014-5793(92)80521-h.

Authors

P J Evans¹, R Evans, I Z Kovar, A F Holton, B Halliwell

Affiliation

¹ Department of Biochemistry, Kings College, London, UK.

PMID: 1376697
DOI: 10.1016/0014-5793(92)80521-h

Abstract

The bleomycin assay measures non-transferrin-bound iron, able to catalyze free radical reactions, in human plasma. No bleomycin-detectable iron is present in plasma from healthy adults. However, plasma from 3/15 premature babies was positive in this assay. Plasma from 52 apparently-healthy term babies was analyzed and 11 were positive in the bleomycin assay. Hence not only some premature but also some full-term apparently-healthy babies may be at risk of severe oxidative damage.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bleomycin
Humans
Hydrogen-Ion Concentration
Infant, Newborn / blood*
Infant, Premature / blood*
Iron / blood*

Substances

Bleomycin
Iron