Abstract
Cyclo-oxygenase-type-2 (COX-2) enzyme is fundamental for nephrogenesis, upregulated on fetal membranes and myometrium at parturition. Fetal COX-2 inhibition, due to maternal nimesulide assumption, can be responsible for neonatal chronic renal failure.
Publication types
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Case Reports
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Comment
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Letter
MeSH terms
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Adult
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Cyclooxygenase Inhibitors / adverse effects*
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Female
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Humans
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Infant, Newborn
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Kidney Failure, Chronic / chemically induced*
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Obstetric Labor, Premature / prevention & control*
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Pregnancy
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Prenatal Exposure Delayed Effects*
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Sulfonamides / adverse effects*
Substances
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Cyclooxygenase Inhibitors
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Sulfonamides
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nimesulide