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Licensed Unlicensed Requires Authentication Published by De Gruyter June 1, 2005

Prolonged fetal bradycardia as the presenting clinical sign in Streptococcus agalactiae chorioamnionitis

  • Giuseppe Presta , Enrico Rosati , Raffaella Giannuzzi , Antonio Del Vecchio , Antonia Lozupone , Mario Criscuolo , Alberto Verrotti , Giuseppe Latini and Claudio De Felice

Abstract

Group B Streptococcus remains a leading infectious cause of neonatal morbidity and mortality. We report a case of a 37 weeks’ gestation infant with severe birth asphyxia, status epilepticus and GBS chorioamnionitis, in which a prolonged fetal bradycardia was the only prenatal clinical sign.

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Corresponding author: G. Latini, MD, Division of Neonatology, Ospedale A. Perrino S.S., 7 per Mesagne, 72100 Brindisi/Italy. Tel.: +39-0831-537471, Fax: +39-0831-537861, E-mail:

References

1 Beinder E, T Grancay, T Menendez, H Singer, M Hofbeck: Fetal sinus bradycardia and the long QT syndrome. Am J Obstet Gynecol185 (2001) 743Search in Google Scholar

2 Bland ML, ST Vermillion, DE Soper, M Austin: Antibiotic resistance patterns of group B streptococci in late third-trimester rectovaginal cultures. Am J Obstet Gynecol184 (2001) 1125Search in Google Scholar

3 Buhimschi C, CP Weiner: Endotoxemia causing fetal bradycardia during urosepsis. Obstet Gynecol97 (2001) 818Search in Google Scholar

4 Covert RF, MD Schreiber: Three different strains of heat-killed group B beta-hemolytic streptococcus cause different pulmonary and systemic responses in conscious neonatal lambs. Pediatr Res33 (1993) 373Search in Google Scholar

5 Dammann O, KC Kuban, A Leviton: Perinatal infection, fetal inflammatory response, white matter damage, and cognitive limitations in children born preterm. Ment Retard Dev Disabil Res Rev8 (2002) 46Search in Google Scholar

6 De Felice C, P Toti, RN Laurini, M Stumpo, E Picciolini, T Todros, P Tanganelli, G Buonocore, R Bracci: Early brain injury in histologic chorioamnionitis. J Pediatr138 (2001) 101Search in Google Scholar

7 Garland SM, F Ni Chuileannain, C Satzke, R Robins-Browne: Mechanisms, organisms and markers of infection in pregnancy. J Reprod Immunol57 (2002) 169Search in Google Scholar

8 Gomez R, R Romero, F Ghezzi, BH Yoon, M Mazor, SM Berry: The fetal inflammatory response syndrome. Am J Obstet Gynecol179 (1998) 194Search in Google Scholar

9 Gull I, AJ Jaffa, M Oren, D Grisaru, MR Peyser, JB Lessing: Acid accumulation during end-stage bradycardia in term fetus: how long is too long? Br J Obstet Gynaecol103 (1996) 1096Search in Google Scholar

10 Hankins GDV, T Leicht, JW Van Hook: Prolonged fetal bradycardia secondary to maternal hypothermia in response to urosepsis. Am J Perinatol14 (1997) 217Search in Google Scholar

11 Hsueh PR, LJ Teng, LN Lee, SW Ho, PC Yang, KT Luh: High incidence of erythromycin resistance among clinical isolates of Streptococcus agalactiae in Taiwan. Antimicrob Agents Chemother45 (2001) 3205Search in Google Scholar

12 Loghis C, E Salamalekis, N Panayotopoulos, N Vitoratos, PA Zourlas: The effect of early second stage bradycardia on newborn status. Eur J Obstet Gynecol72 (1997) 149Search in Google Scholar

13 Morikawa Y, M Kitazato, C Katsukawa, A Tamaru: Prevalence of cefotaxime resistance in group B streptococcus isolates from Osaka, Japan. J Infect Chemother9 (2003) 131Search in Google Scholar

14 Newton ER: Chorioamnionitis and intraamniotic infection. Clin Obstet Gynecol36 (1993) 79510.1097/00003081-199312000-00004Search in Google Scholar PubMed

15 Peevy KJ, SA Chartrand, HJ Wiseman, RC Boerth, RD Olson: Myocardial dysfunction in group B streptococcal shock. Pediatr Res19 (1985) 511Search in Google Scholar

16 Rounioja S, J Rasanen, V Glumoff, M Ojaniemi, K Makikallio, M Hallman: Intra-amniotic lipopolysaccharide leads to fetal cardiac dysfunction. A mouse model for fetal inflammatory response. Cardiovasc Res60 (2003) 156Search in Google Scholar

17 Schrag S, R Gorwitz, K Fultz-Butts, A Schuchat: Prevention of perinatal group B streptococcal disease. Revised guidelines from CDC. MMWR Recomm Rep51 (2002) 1Search in Google Scholar

18 Shalak LF, JM Perlman: Infection markers and early signs of neonatal encephalopathy in the term infant. Ment Retard Dev Disabil Res Rev8 (2002) 14Search in Google Scholar

19 Yanowitz TD, JA Jordan, CH Gilmour, R Towbin, A Bowen, JM Roberts, BS Brozanski: Hemodynamic disturbances in premature infants born after chorioamnionitis: association with cord blood cytokine concentrations. Pediatr Res51 (2002) 310Search in Google Scholar

Published Online: 2005-06-01
Published in Print: 2004-11-04

© Walter de Gruyter

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