Chest
Volume 114, Issue 5, Supplement, November 1998, Pages 511S-523S
Hemorrhagic Complications of Anticoagulant Treatment
Section snippets
Oral Anticoagulants
The major determinants of oral anticoagulant-induced bleeding are the intensity of the anticoagulant effect, patient characteristics, the use of drugs that interfere with hemostasis, and the length of therapy.
Heparin
Heparin is usually given in low doses by subcutaneous injection to prevent venous thrombosis (prophylactic heparin), in higher doses to treat patients with acute venous thromboembolism or with acute coronary syndromes (therapeutic heparin), and in very high doses in patients during open heart surgery.
In this chapter, we will discuss only bleeding associated with therapeutic heparin. Heparin has the potential to induce bleeding by inhibiting blood coagulation, by impairing platelet function,101
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Copyright © 1998 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.