Elsevier

The Journal of Pediatrics

Volume 137, Issue 6, December 2000, Pages 891-892
The Journal of Pediatrics

Why young children are resistant to acetaminophen poisoning

https://doi.org/10.1067/mpd.2000.107624Get rights and content

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To the Editor:

I read with interest the article by Anderson et al entitled “Predicting concentrations in children presenting with acetaminophen overdose.”1 They begin with the statement “Severe liver toxicity caused by a single dose of acetaminophen (paracetamol) elixir is rare in children 1 to 5 years.” In fact, this is true for all dosage forms of acetaminophen. On literature review, beyond two publications,2, 3 one would be hard pressed to find a well-documented case of severe hepatic toxicity caused by a

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