Why young children are resistant to acetaminophen poisoning
Section snippets
To the Editor:
I read with interest the article by Anderson et al entitled “Predicting concentrations in children presenting with acetaminophen overdose.”1 They begin with the statement “Severe liver toxicity caused by a single dose of acetaminophen (paracetamol) elixir is rare in children 1 to 5 years.” In fact, this is true for all dosage forms of acetaminophen. On literature review, beyond two publications,2, 3 one would be hard pressed to find a well-documented case of severe hepatic toxicity caused by a
References (9)
- et al.
Predicting concentrations in children presenting with acetaminophen overdose
J Pediatr
(1999) - et al.
Metabolism and pharmacokinetics of acetaminophen in a severely poisoned young child
J Pediatr
(1984) - et al.
Acetaminophen overdose
Emerg Med Clin North Am
(1984) Acetaminophen overdose in young children. Treatment and effects of alcohol and other ingestants in 417 cases
Am J Dis Child
(1984)
There are more references available in the full text version of this article.
Cited by (11)
Acute paracetamol overdose during pregnancy: A case report
2011, Archives de PediatrieAcute acetaminophen poisoning in children: Kids aren't just little adults [2]
2003, Journal of Emergency MedicineThe effects of analgesia in the vulnerable infant during the perinatal period
2002, Clinics in PerinatologyReply
2014, Netherlands Journal of MedicineIntentional paracetamol intoxication in children
2011, Nederlands Tijdschrift voor GeneeskundePediatric models for adult target-controlled infusion pumps
2010, Paediatric Anaesthesia
Copyright © 2000 Mosby, Inc. All rights reserved.