General Obstetrics and Gynecology: ObstetricsThe Maternal Lifestyle Study: Drug exposure during pregnancy and short-term maternal outcomes☆,☆☆
Section snippets
Methods
The entire population of mother-infant dyads who agreed to participate, whether exposed or comparison, constituted the phase I study. This study was reviewed and approved by the institutional review board at each of the four participating institutions. Each of the sites obtained an NIDA Certificate of Confidentiality, which ensured confidentiality of information to be solicited from the participants regarding their drug use, and superseded the mandatory reporting of known drug abuse that was in
Results
Recruitment occurred from May 1993 to May 1995, during which 19,079 mothers were screened at the four sites (Table I).Empty Cell Detroit (3633) Memphis (4898) Miami (5606) Providence (4942) Total (19,079) A. Total number screened 501-1500 355 (10) 479 (10) 396 (7) 231 (5) 1461 (8) 1501-2500 849 (23) 1190 (24) 828 (15) 693 (14) 3560 (19) >2500 2429 (67) 3229 (66) 4382 (78) 4018 (81) 14,058 (74) B. Total number eligible* 3208 (88)
Comment
Cocaine or opiate use during pregnancy is part of a spectrum of complex, high-risk behaviors that has been reported to result in significantly increased complications for both the mother and infant. A notable result of this large cohort study, which assessed 8627 postpartum women, was its documentation of the relative low frequency of detrimental acute effects compared with previous reports. Many previous drug abuse studies have relied primarily on maternal report. The protection of
Acknowledgements
We thank Elisabeth Ravelo for preparation of this manuscript and John Langer, Kenneth Poole, and Abik Das of Research Triangle Institute (RTI), Research Triangle Park, NC, for their assistance and their review of this manuscript.
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Cited by (0)
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Supported by the National Institute of Child Health and Human Development through cooperative agreements (No. U10 HD 21397),a(No. U10 HD 21385),b(No. U10 HD 27856),c(No. U10 HD 27904),dand (No. U01 HD 19897),fand intra-agency agreements with the National Institute on Drug Abuse, Administration on Children, Youth and Families, and the Center for Substance Abuse Treatment. (CSAT)
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Reprint requests: Charles R. Bauer, MD, University of Miami, Department of Pediatrics (R-131), PO Box 016960, Miami, FL 33101. E-mail: [email protected]