Am J Perinatol 2004; 21(2): 73-77
DOI: 10.1055/s-2004-820515
Copyright © 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA

Extended Interval Dosing of Gentamicin in Preterm Infants

Ma. Cecilia K. Mercado1 , Nancy L. Brodsky1 , 3 , Michael K. McGuire2 , Hallam Hurt1 , 3
  • 1Division of Neonatology, Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, Pennsylvania
  • 2Department of Pharmacy, Albert Einstein Medical Center, Philadelphia, Pennsylvania
  • 3Current affiliation: Department of Neonatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Further Information

Publication History

Publication Date:
11 March 2004 (online)

Conventional interval dosing (CID) and extended interval dosing (EID) of gentamicin were compared in preterm infants. Gentamicin peak and trough levels, serum creatinine, urine output, and hearing screens were obtained in 40 preterm infants. Results suggest that EID is safe, provides gentamicin levels in desirable ranges (peak, 5 to 12 μg/mL; trough <2 μg/mL), and reduces dosage adjustments.

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Hallam HurtM.D. 

Children's Hospital of Philadelphia, Division of Neonatology

34th Street and Civic Center Blvd

Philadelphia, PA 19104

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