Regular ArticleAlloimmune thrombocytopenia of the fetus and the newborn
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2014, Early Human DevelopmentDiagnosis and Management of Neonatal Alloimmune Thrombocytopenia in Pregnancy
2013, Clinics in Laboratory MedicineCitation Excerpt :In these cases ICH tends to occur earlier than in the sibling. An intraparenchymal bleed can occur as early as 16 weeks gestational age because IgG alloantibodies can cross the placenta as early as Week 14 of pregnancy, and fetal GPs are expressed on platelets starting at 16 weeks gestational age.7 For all hemorrhagic complications, including ICH, bleeding and symptoms may be delayed, because the platelet count usually falls further during the first several days of life.
Alloimmune Thrombocytopenia
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2012, Platelets, Third EditionDiagnosis and Management of Neonatal Alloimmune Thrombocytopenia
2008, Transfusion Medicine ReviewsCitation Excerpt :Up to 80% of ICH occur in utero,11,12,14 as early as 16 weeks' gestation,15-17 which may lead to structural and/or metabolic central nervous system abnormalities including hydrocephaly, porencephalic cysts, neuronal migrational disorders, and superficial siderosis.15,18,19 Bleeding at other anatomical sites is unusual.20 A history of NAT in a sibling is the most important predictor of NAT.21
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Correspondence to: Cécile Kaplan, MD, Institut National de Transfusion Sanguine, 6 rue Alexandre Cabanel, 75739 Paris, Cedex 15, France. Tel: 33 1 44 49 30 66; Fax: 01 45 67 19 30. E-mail: [email protected]