Elsevier

Seminars in Neonatology

Volume 6, Issue 2, April 2001, Pages 121-133
Seminars in Neonatology

Regular Articles
Cerebral white matter damage in the preterm infant: pathophysiology and risk factors

https://doi.org/10.1053/siny.2001.0043Get rights and content

Abstract

Based on clinical, epidemiologic, and experimental studies, the aetiology of white matter damage, specifically periventricular leukomalacia (PVL), is multifactorial and involves pre- and perinatal factors possibly including genetic factors, hypoxic-ischaemic insults, infection, excess cytokines, free radical production, increased excitatory amino acid release, and trophic factor deficiencies. The article summarizes research findings about the aetiology of white matter damage and cerebral palsy in preterm infants. The information is organized according to specific antecedents, for which we present epidemiological and neurobiological data. The most important prenatal factor appears to be intrauterine infection. We discuss the evidence supporting the hypothesis that the foetal inflammatory response contributes to neonatal brain injury and later developmental disability. We recently established an animal model of excitotoxic lesions in the developing mouse brain. Brain damage was induced by intra-cortical injections of ibotenate, a glutamatergic agonist. When administered on post-natal day 5 ibotenate induced the formation of white matter cysts. Our animal model could be used to further explore the mechanisms involved in the formation of PVL. Potentially preventive strategies will be discussed.

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    Correspondence to Elie Saliba, INSERM U 316, Department of Neonatology, Hôpital Clocheville, 49, Bd Béranger F-37000, France. E-mail:[email protected]

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