Pathology of Bronchopulmonary Dysplasia
Section snippets
Similarities/Differences in the Pathology of Animal Models of BPD in Relation to Human BPD
Bronchopulmonary dysplasia is the end result of lung injury in a developmentally immature host, so developmental similarities should exist between the animal model and the human disease. The immature infant will breathe some level of oxygen, and even room air represents a hyperoxic exposure. Because ventilator-induced lung injury plays a significant role in the pathogenesis of BPD, studies would require that volutrauma or biotrauma be mechanistically examined. The presence of a predelivery
Acknowledgement
This work is supported in part by NIH Grant HL52636.
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