PAPS PapersEffect of propranolol vs prednisolone vs propranolol with prednisolone in the management of infantile hemangioma: A randomized controlled study
Section snippets
Material and methods
Thirty patients with IHs attending the outpatient department of a tertiary referral hospital from January 2011 to July 2012 complying with the following criteria were included in the study: age group—1 week to 8 months of either sex and problematic IHs with potentially disfiguring lesions in the face or functionally threatening lesions of the limbs, genitalia or natural orifices. The following were excluded: uncomplicated lesions of trunk, extremities; presence of heart disease, cardiac
Results
The overall male/female ratio was 3:2. (A 2.1:1, B 2:3 and C 2.1:1). No patient was on any concomitant therapy at the time of initiation of treatment.
Mean age of initiation of treatment was 4.6 months (1–8) in group A, 5.5 months (2–8) in group B and 4.7 (1–8) months in group C. Head and neck were the most common locations in 66% (n = 20). Parotid was the most common site in head and neck region contributing 30% of total cases, followed by lip (13.3%) and scalp (10%). The most common type of lesion
Discussion
Hemangiomas are benign growths of endothelial cells presenting anywhere in the skin, mucous membranes, or underlying viscera. They most commonly occur in the head and neck region as seen in our study also where they accounted for 66% of the cases [5]. There were more males than females (3:2) in our study as compared to the literature where it is quoted to occur 2.2 to 4.5 times more often in females [1].
Up to 10% of IHs may cause obstruction of the upper airway/eye, ulceration, bleeding,
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2023, Journal of Investigative DermatologyThe effectiveness of oral propranolol for infantile hemangioma on the head and neck region: A case series
2021, International Journal of Surgery Case ReportsCitation Excerpt :It is used primarily during the proliferative phase of IH. However, some research found that prednisolone is less effective than propranolol and is associated with significantly more adverse events [13,14]. Other medications used include imiquimod, vincristine, bleomycin A5, and interferon-a; however, they are abandoned due to serious side effects [15].
Treatments for infantile Hemangioma: A systematic review and network meta-analysis
2020, EClinicalMedicineSurgical resection of infantile hemangiomas following medical treatment with propranolol versus corticosteroids
2019, Journal of Pediatric SurgeryCitation Excerpt :Through this proposed mechanism propranolol resulted in increased improved resolution of IH when compared to placebo treatment [5,7]. Subsequent prospective randomized trials comparing propranolol to corticosteroids found propranolol to be superior; however, a recent trial found both medications to be highly effective with > 90% response rates [6,12]. One option for patients without adequate response to medication is surgical resection [8].