Original ArticleOutcomes of Small for Gestational Age Infants Born at <27 Weeks' Gestation
Section snippets
Methods
This study was a retrospective cohort analysis of data collected prospectively from the National Institute of Child Health and Human Development's Neonatal Research Network (NRN) Generic Database and Follow-Up Studies. Infants born in one of the participating NRN sites between January 2006 and July 2008 were included if they were born between 23 and 26 6/7 weeks GA. Infants with major congenital anomalies or syndromes and those who declined neurodevelopmental follow-up were excluded from the
Results
The study population comprised 2971 infants born between 23 0/7 and 26 6/7 weeks GA, including 385 SGA infants and 2586 non-SGA infants (Figure; available at www.jpeds.com). Compared with the non-SGA group, mothers of infants in the SGA group were more likely to have received prenatal care and antenatal corticosteroids, to have experienced pregnancy-induced hypertension, and to have a high school education. SGA infants were more likely to be delivered by cesarean delivery and to have a 5-minute
Discussion
In our study cohort, there was a significantly higher rate of maternal pregnancy-induced hypertension in the SGA group compared with the non-SGA group. Non-SGA infants had higher rates of neonatal morbidities, including RDS, surgically treated patent ductus arteriosus and grade III-IV ICH, whereas SGA infants had a higher rate of antenatal corticosteroid use and longer durations of mechanical ventilation and hospitalization. Despite their lower rate of prematurity-associated morbidities, the
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The National Institutes of Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Center for Research Resources, and the National Center for Advancing Translational Sciences provided grant support for the Neonatal Research Network's Generic Database and Follow-up Studies. Data collected at participating sites of the NICHD Neonatal Research Network were transmitted to RTI International, the data coordinating center for the network; which stored, managed and analyzed the data for this study. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors declare no conflicts of interest.
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A list of members of the Eunice Kennedy Shriver National Institute of Health and Human Development Neonatal Research Network are available at www.jpeds.com (Appendix).