Original articleA 10-Year Prospective Study of Sensorineural Hearing Loss in Children with Congenital Cytomegalovirus Infection
Section snippets
Methods
The study protocol was approved by the Committee of Medical Ethics of the Universitair Ziekenhuis Brussel.
Results
Of the 14 021 infants born in UZ Brussels Hospital between June 1996 and November 2006, 74 (0.53%) were diagnosed with a cCMV infection (33 boys and 41 girls). Four of these infants (5.4%) had a symptomatic infection, and 70 (94.6%) had an asymptomatic infection. A total of 13 infants were lost to follow-up, and 1 infant with a symptomatic cCMV infection died before a hearing test could be performed. Hearing tests were conducted in the remaining 60 congenitally infected infants (3 symptomatic
Discussion
Among 14 000 unselected live-born infants studied prospectively over a 10-year period in a single hospital, the incidence of cCMV was 0.53%, with 5.4% of cases symptomatic. Hearing loss was found in 22% of the cCMV-infected infants (21% of the asymptomatic and 33% of the symptomatic infected infants). Previous studies have put the incidence of SNHL at 6% to 25%9, 10, 11 in infants with asymptomatic cCMV infection and 22% to 65% in infants with symptomatic cCMV infection.11 The incidence of SNHL
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