Current Biology
Volume 4, Issue 7, July 1994, Pages 662-665
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Neurotrophins: Keeping track of changing neurotrophic theory

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Abstract

The requirement for neurotrophins in the development of specific neuronal populations is endorsed by transgenic mice lacking neurotrophin receptors, but central nervous regions of the mice are paradoxically unaffected.

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One of the more remarkable events to occur during development of the vertebrate nervous system is the normal death of a large proportion of neurons. In virtually every region of the nervous system, large numbers of neurons die during a restricted period that coincides with their innervation of target tissues [1]. Early targetablation and transplantation experiments by the neuro-embryologist Viktor Hamburger demonstrated that many neurons are dependent upon their targets for essential trophic

James Johnson and Ronald Oppenheim, Department of Neurobiology and Anatomy, and Program in Neuroscience, Bowman Gray School of Medicine of Wake Forest University, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1010, USA.

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James Johnson and Ronald Oppenheim, Department of Neurobiology and Anatomy, and Program in Neuroscience, Bowman Gray School of Medicine of Wake Forest University, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1010, USA.

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