Current Biology
DispatchNeurotrophins: Keeping track of changing neurotrophic theory
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One of the more remarkable events to occur during development of the vertebrate nervous system is the normal death of a large proportion of neurons. In virtually every region of the nervous system, large numbers of neurons die during a restricted period that coincides with their innervation of target tissues [1]. Early targetablation and transplantation experiments by the neuro-embryologist Viktor Hamburger demonstrated that many neurons are dependent upon their targets for essential trophic
James Johnson and Ronald Oppenheim, Department of Neurobiology and Anatomy, and Program in Neuroscience, Bowman Gray School of Medicine of Wake Forest University, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1010, USA.
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James Johnson and Ronald Oppenheim, Department of Neurobiology and Anatomy, and Program in Neuroscience, Bowman Gray School of Medicine of Wake Forest University, Medical Center Boulevard, Winston-Salem, North Carolina 27157-1010, USA.