Does cryotherapy affect refractive error?: Results from treated versus control eyes in the cryotherapy for retinopathy of prematurity trial1☆,
Section snippets
Patients
The study population consisted of the 291 children who participated in the randomized trial of cryotherapy for ROP. All were born between January 1, 1986, and November 30, 1987, with birth weights less than 1251 g. During the neonatal period, 240 of the infants developed bilateral severe (threshold) ROP, defined as a minimum of five contiguous or eight cumulative clock hours of stage 3+ ROP in zone 1 or zone 2. In these infants, one eye was randomly assigned to undergo cryotherapy and the other
Spherical equivalent refractive errors
Figure 1 shows the distribution of spherical equivalent refractive errors for all treated (dark bars) and all control (hatched bars) eyes at the 10 test ages. At all ages, the proportion of eyes that could not be refracted is approximately twice as great in the control group as the treated group, as reported previously.11, 13 Among eyes that could be refracted at 3 months, the distribution of refractive errors in treated eyes was similar to that for control eyes. At all other test ages, the
Discussion
When evaluating any therapeutic method, the clinician must consider possible adverse results of the treatment. It has been suggested that cryotherapy increases the likelihood of high degrees of myopia in eyes with severe ROP.4 The comparison of refractive errors in all eyes that underwent cryotherapy and all eyes that served as controls is presented in this paper. Figure 1 indicates that, at all 10 follow-up ages, the distribution of refractive error in the range from less than 8 D of myopia to
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Retinopathy of prematurity in India – what can we learn from the polio legacy?
2023, The Lancet Regional Health - Southeast AsiaLongitudinal Change of Refractive Error in Retinopathy of Prematurity Treated With Intravitreal Bevacizumab or Laser Photocoagulation
2022, American Journal of OphthalmologyComparison of intravitreal bevacizumab injection and laser photocoagulation for type 1 zone II retinopathy of prematurity
2019, Journal of Current OphthalmologyCitation Excerpt :Wu and coworkers reported cataract formation in 1% of eyes following IVB injection for ROP.9 CRYO-ROP and ET-ROP trials and some other studies reported that myopia and high myopia increased significantly after ablation of peripheral retina for the treatment of ROP.23–27 Gelonek et al. compared the refractive outcomes following IVB injection and laser photocoagulation.28
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Supported by the National Eye Institute, Bethesda, Maryland (cooperative agreement no. U10 EY05874).
- 1
A listing of cooperative group participants can be found in Archives of Ophthalmology 1996;114:417–24.
- 2
Reprint requests to CRYO-ROP Study Headquarters, Oregon Health Sciences University, Department of Ophthalmology, L467, 3375 SW Terwilliger Boulevard, Portland, OR 97201-4197 (Earl A. Palmer, MD).