Use of unproven therapies in clinical practice and research: How can we better serve our patients and their families?

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  • Cited by (23)

    • Optimizing Participation of Pregnant Women in Clinical Trials: Factors Influencing Decisions About Participation in Medication and Vaccine Trials

      2016, Journal of Obstetrics and Gynaecology Canada
      Citation Excerpt :

      Pregnancy-mediated physiologic changes to the maternal immune system may also result in differences in the degree of protective immunogenic reaction produced in response to vaccination during pregnancy.5 Ironically, current regulations limiting research in pregnancy may have the unintended consequence of exposing a greater number of pregnant women to harm through the off label use of unproven therapies in clinical practice.6 Additionally, the systematic exclusion of pregnant women from pharmaceutical research studies has had identifiable negative effects on maternal and perinatal morbidity and mortality.

    • Ethical Decisions in the Neonatal-Perinatal Period

      2005, Avery's Diseases of the Newborn
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